The availability of well-defined quality control sera (positive human sera) is essential for the development, production, evaluation, standardization and quality control for Allergy in-vitro Test Systems. However, human control sera are not existent for all allergens. In addition, serum samples from commercial serum banks (often serum pools) show often variable quality and are normally very expensive. Another reason for variable or different results between the test systems may be that the allergens are coming from different sources, raw materials and different manufacture processes, release procedures and storage conditions. Standardized reference material is not available for the determination of allergen-specific Immunoglobulin E. The use of artificial human sera could be a step for the standardization of Allergy in-vitro Test Systems.
ARTHUS-sIgE controls are produced by fusion of the human IgE-Fc-region and allergen-specific antibodies from rabbits. The allergen-specific rabbit antibodies are generated by immunization with recombinant or highly purified allergens as well as allergen extracts. The fusion of the allergen-specific antibodies with the human IgE-Fc-region results in ARTHUS which can be used for the determination of human specific IgE antibodies.
ARTHUS-sIgE controls have to be handled as normal serum samples according to the instructions for use supplied with the kit.
ARTHUS-sIgG-Controls are available for the most important Autoimmune antigens. They can add to the standardization of Autoimmune diagnostics.
ARTHUS-sIgG4 Controls can add to the standardized diagnosis of follow-up of Immunotherapies. The functionality of ARTHUS-sIgG4 controls in different systems is already confirmed.
|ARTHUS spec. for||Allergen-Code||REF|
|Penicilloyl G||c1||07Ac0001 -01 / -10|
|Dermatophagoides pteronyssinus||d1||07Ad0001 -01 / -10|
|Peanut||f13||07Af0013 -01 / -10|
|Hazelnut||f17||07Af0017 -01 / -10|
|Alpha – Lactalbumin||f76||07Af0076 -01 / -10|
|Beta – Lactoglobulin||f77||07Af0077 -01 / -10|
|Phospholipase A||i11||07Ai0011 -01 / -10|
|Hevea brasiliensis||k82||07Ak0082 -01 / -10|
|Aspergillus fumigatus||m3||07Am0003 -01 / -10|
|Ves v 5 Wasp Venom||ri305||07ARI305 -01 / -10|
|Bet v 1 Birch||rt301||07ART301 -01 / -10|