Publikationen

PUBLICATIONS

Oral Presentations

Poster Presentations

Manuscripts

Book Chapters

Oral Presentations

Mahler M, Koenig M, Senécal JL, Csernok E, Arnett FC, Riemekasten G, Fritzler MJ: Sero-Clinical aspects of autoantibodies to a PM/Scl peptide with special emphasis on a cohort of 495 systemic sclerosis patients. 5^th Congress on autoimmunity held in Sorrento, Italy 2006.
Mahler M, Greidinger EL, Fritzler MJ: Serological and clinical characterization of anti-DNA and anti-PM/Scl double positive samples. 5^th Congress on autoimmunity held in Sorrento, Italy 2006.
Mahler M and Fritzler MJ: Novel aspects of autoantibodies to the human exosome (PM/Scl complex). 8^th Dresden Symposium on Autoantibodies, Germany 2007.
Mahler M, Lorenz C, Fooke M and Kleine-Tebbe J: Comparison between skin prick test and a reversed enzyme allergo-sorbent test. 20^th World allergy congress held in Bangkok, Thailand 2007. Abstract published in World Allergy Organization Journal & November 2007.
Mahler M: Autoantibodies to the ribosomal P antigens in autoimmunity, allergy and infectious diseases. 10^th International Workshop on Autoantibodies & Autoimmunity held in Guadalajara, Mexico 2008.
Mahler M and Fritzler MJ: Novel diagnostic aspects of anti-PM/Scl autoantibodies. 6^th Congress on autoimmunity held in Porto, Portugal 2008.
Schulte-Pelkum J, Simon T, Szmyrka-Kaczmarek M, Fritzler MJ, Mahler M: Latest update on the Ro/SS-A autoantibody system. 6^th Congress on autoimmunity held in Porto, Portugal 2008.
Mahler M, Lucassen R, Fooke M. Reliable rapid detection of allergen-specific and total IgE in the diagnosis of type I hypersensitivity using a novel allergy lateral flow assay (ALFA). The European Histamine Research Society 38^th Annual Meeting held in Fulda, Germany, 2009.
Lucassen R, Mahler M, van Helden J and Fooke M. Evaluation of an allergy lateral flow assay for the detection of specific IgE to food allergens. 28^th Congress of the European Academy of Allergology and Clinical Immunology held in Warsaw, Poland 2009.
Mahler M, Fritzler MJ. Peptide resolved diagnostics in systemic autoimmune diseases: Potentials and Pitfalls. 9^th Dresden Symposium on Autoantibodies, Germany 2009.
Offermann N, Petschinka M, Fooke M: Evaluation of a novel sensitive and specific Lateral Flow Assay (LFA) for the detection of anti-dsDNA antibodies – Anti-dsDNA LFA. 11^th Dresden Symposium on Autoantibodies, Germany 2013.
Offermann N, Plum M, Rathloff K, Sundermann U, Fooke M, Spillner E: Establishment of Artificial Human Sera (ARTHUS) based on Chimeras of FcgammaRI and Human Immunoglobulin Domains. 35th Congress of the European Academy of Allergology and Clinical Immunology, Barcelona, Spain 2015.

Poster Presentations

Kleine-Tebbe J, Breuer K, Lepp U, Vieths S, Worm M, Kunkel G, Wahn U, Lau S: Allergen-sepcific IgE-values to inhalant and food allergens – Comparison between two commercial immunoassays: Dr. Fooke ALLERG-O-LIQ versus Pharmacia CAP-System. 23^rd EAACI congress held in Paris, France 2004.
Duyan I, Mahler M, Hoff M, Fooke M: Technical and clinical evaluation of a fully automated Reversed Enzyme Allergo Sorbent Test (REAST) using liquid biotinylated allergens. 13^th national allergy and clinical immunology congress held in Izmir, Turkey 2005.
Fritzler MJ, Mahler M, Fritzler ML: Autoantibodies in a cohort of sera that contain anti-Jo-1 (histidyl-tRNA synthetase) antibodies. 9^th International Workshop on Autoantibodies & Autoimmunity held in Gainesville, Florida, USA 2005.
Mahler M, Raijmakers R, Fritzler ML, Fritzler MJ: Anti-PM1-Alpha antibodies are frequently accompanied by antibodies to GW bodies in patients with PM/Scl overlap syndrome. 9^th International Workshop on Autoantibodies & Autoimmunity held in Gainesville, Florida, USA 2005.
Kessenbrock K, Fritzler MJ, Mahler M: Structural analysis of the major ribosomal P epitope C22. 9^th International Workshop on Autoantibodies & Autoimmunity held in Gainesville, Florida, USA 2005.
Lucassen R, Fooke M, Kleine-Tebbe J, Mahler M: Development and evaluation of a rapid assay for the diagnosis of ty pe I allergies. 26^th EAACI congress held in Gothenburg, Sweden 2007. Abstract published in Allergy 2007, 62 (Suppl. 83, poster 1242): 167-551.
Mahler M, Lorenz C, Lucassen L, Fooke M, Kleine-Tebbe K: Clinical evaluation of a new allergy lateral flow assay for professional and home use. 20^th World allergy congress held in Bangkok, Thailand 2007.
Sun B, Mei J, Jing L, Zhong N: Allergen-specific IgE to inhalant and food allergens and total IgE values in China – Comparison between two commercial immunoassays: Dr. Fooke ALLERG-O-LIQ versus Phadia ImmunoCAP® System. 20^th World allergy congress held in Bangkok, Thailand 2007.
Sager A, Lauter H: Sensitization and clinical relevance of ragweed pollen in patients with intermittent rhinoconjunctivitis. 20^th World allergy congress held in Bangkok, Thailand 2007.
Lauter H, Sager A: Sensibilisierung und klinische Relevanz von Beifuß-Ambrosie im Hochsauerland bei Patienten mit Heuschnupfen. Allergo J 2007, 16: (Poster 34) S64.
Fritzler MJ, Ngo J, Hou H, Mahler M: Limited reliability of the indirect immunofluorescence technique for the detection of anti-Rib-P antibodies. 10^th International Workshop on Autoantibodies & Autoimmunity held in Guadalajara, Mexico 2008.
Mahler M, Eissfeller P, Silverman ED, Fritzler MJ: Diagnostic value of a novel ANA Screen ELISA. 10^th International Workshop on Autoantibodies & Autoimmunity held in Guadalajara, Mexico 2008.
Lucassen R, Mahler M, Fooke M: Development and evaluation of a new rapid assay for semi-quantitative detection of total IgE in human serum and cappilary blood. 27^th Congress of the European Academy of Allergology and Clinical Immunology held in Barcelona, Spain 2008.
Lucassen R, Fooke M, Lorenz C, Kleine-Tebbe J, Mahler M: Evaluation of a rapid assay for the diagnosis of type I allergy. 27^th Congress of the European Academy of Allergology and Clinical Immunology held in Barcelona, Spain 2008.
Mahler M, Eissfeller P, Fritzler ML and Fritzler MJ: Anti-PCNA antibodies in samples with cell cycle dependent, PCNA-like indirect immunofluorescence staining pattern. 6^th Congress on autoimmunity held in Porto, Portugal 2008.
Mahler M, Mierau R, Humbel R and Fritzler MJ: Anti-PM1-Alpha antibodies: Analytical evaluation in two centers. 6^th Congress on autoimmunity held in Porto, Portugal 2008.
Schulte-Pelkum J, Mahler M, Szmyrka-Kaczmarek M, Petschinka M, Simon M and Fritzler MJ: Evaluation of recombinant Ro60 for diagnostic use in AI-Line ELISA. 6^th Congress on autoimmunity held in Porto, Portugal 2008.
Mahler M, Petschinka M, Lüttich T, Hiepe F, Szmyrka-Kaczmarek M and Fritzler MJ: Anti-topo-I/Scl-70 autoantibodies in systemic lupus erythematosus: Myth or reality? 6^th Congress on autoimmunity held in Porto, Portugal 2008.
Mahler M, Fooke M: Detection of allergen-specific IgE using the ALLERG-O-LIQ System based on the Reversed-enzyme-allergo-sorbent-test. The European Histamine Research Society 38^th Annual Meeting held in Fulda, Germany, 2009.
Ngo J, Mahler M, Fritzler MJ: A Comparison between old and newer methods for the detection of Anti-Ribosomal P Autoantibodies. 2009 Canadian Rheumatology Association Conference and annual meeting held in Delta Kananaskis, Kananaskis, Alberta 2009.
Lucassen R, Schulte-Pelkum J, Mahler M, Kleine-Tebbe J, Csuvarszki C and Fooke M: Development and evaluation of a scanner based allergy lateral flow assay system for the determination of specific IgE. 28^th Congress of the European Academy of Allergology and Clinical Immunology held in Warsaw, Poland 2009.
Mahler M, Agmon-Levin N, van Liempt M, Shoenfeldt Y, Waka A, Hiepe F, Swart A, et al.,. Multi-center evaluation of autoantibodies to the major ribosomal P epitope C22. Ann Rheum Dis 2009, 28: Suppl 3, 514.
Mahler M, van Liempt M, Schulte-Pelkum J, Schneider S, Alexander T, Kromminga A,. Fooke M, Hiepe F: Evaluation of a novel dsDNA ELISA for SLE disease activity measurement. 9^th Dresden Symposium on Autoantibodies, Germany 2009.
Mahler M, Siegemund M, Meyer W, Petschinka M, Fritzler MJ: Anti-PM/Scl-antibodies in systemic sclerosis: Comparison between PM1-Alpha ELISA and a line assay with recombinant PM/Scl-75c and PM/Scl-100. 9^th Dresden Symposium on Autoantibodies, Germany 2009.
Swart A, Mahler M, Fritzler MJ: The cell cycle protein Nop52 is a candidate target autoantigen. 9^th Dresden Symposium on Autoantibodies, Germany 2009.
Mahler M, Schulte-Pelkum J, van Liempt M, Wither JE, Fooke M, Fritzler MJ: ANTI-CENP-A AND CENP-B ANTIBODIES IN SLE. 7th International Congress on Autoimmunity, Slowenia 2010
Pfender N, Mahler M, Offermann N, Lucassen R, Fooke M, Jakob T: Comparison between two systems for the detection of specific IgE to bee and wasp venom. 29th Congress of the European Academy of Allergology and Clinical Immunology England 2010,
Pfender N, Mahler M, Offermann N, Lucassen R, Fooke M, Jakob T: Evaluation of a novel rapid test system for the detection of specific IgE to bee and wasp venom. 29th Congress of the European Academy of Allergology and Clinical Immunology England 2010.
Lucassen R, Pfender N, Mahler M, Offermann N, Fooke M, Jakob T: Evaluation of a rapid test system for the detection of specific IgE to cross-reactive carbohydrates. 29th Congress of the European Academy of Allergology and Clinical Immunology England 2010.
Lucassen R, Schulte-Pelkum J, Petschinka M, Fooke M: New highly sensitive and specific Lateral flow tests for the detection of proteinase 3 and myeloperoxidase antibodies. Report on the 10th Dresden Symposium on Autoantibodies 2011, Poster: 694-695.
Najm C, Bennaroch L, Camacho N, Figueroa D, Guzmán J, Perdomo A et al.: Frequency of Food Hypersensitivity Mediated by IgG in Patients Received in a Venezuelan Laboratory During 2011. In: XXII WORLD ALLERGY CONGRESS; Cancun, Mexico. Poster 2087.
Schulte-Pelkum J, Offermann N, Fooke M: New highly sensitive and specific Lateral Flow Tests for the detection of Proteinase 3, Myeloperoxidase and Glomerular Basement Membrane antibodies. 8th International Congress on Autoimmunity May 9-13th 2012, Granada, Spain 2012, Poster: 234.
Offermann N, Rubina AY, Fooke M: Evaluation of a new multiplex assay system for the simultaneous detection of specific IgE to 21 allergens against an established immunological assay method – Preliminary data. Congress of the European Academy of Allergology and Clinical Immunology and World Allergy Organization, Milan, Italy 2013.
Offermann N, Petschinka M, Fooke M: Evaluation of a novel sensitive and specific Lateral Flow Assay (LFA) for the detection of anti-dsDNA antibodies – Anti-dsDNA LFA. 11^th Dresden Symposium on Autoantibodies, Germany 2013.
Ay B, Offermann N, Horlitz M, Fooke M: Peptides as antigens for specific IgE detection in cow’s milk allergy patients using a reversed enzyme immunoassay. Congress of the European Academy of Allergology and Clinical Immunology, Copenhagen, Denmark 2014.
Nadine Offermann, Melanie Plum, Kerstin Rathloff, Uschi Sundermann, Margrit Fooke, Edzard Spillner: Establishment of Artificial Human Sera (ARTHUS) based on Chimeras of FcgammaRI and Human Immunoglobulin Domains. Congress of the European Academy of Allergology and Clinical Immunology, Barcelona, Spain 2015.
Uschi Sundermann, Miriam Britsch, Nadine Offermann, Margrit Fooke: Heterologous production of food- and pollen-related allergen components for the detection of sensitization patterns. Congress of the European Academy of Allergology and Clinical Immunology, Barcelona, Spain 2015.
Offermann N, Plum M, Miehe M, Hübner U, Fooke M, Spillner E. Artifical Human Sera (ARTHUS) as a tool for validation and standardization of bee and wasp specific in-vitro diagnostic systems. 37th Congress of the European Academy of Allergology and Clinical Immunology, Helsinki, Finland 2017
Offermann N, Plum M, Miehe M, Hübner U, Fooke M, Spillner E. Establishment of Artificial Human Sera (ARTHUS) based on Chimeras of FcgammaRI and Human Immunoglobulin Domains. 35th Congress of the European Academy of Allergology and Clinical Immunology, Barcelona, Spain 2015
Plum M, Rathloff K, Offermann N, Jakob T, Fooke M, Spillner E. Artificial Human Reference Sera established by CD64-IgE Fusion Proteins. 32th Congress of the European Academy of Allergology and Clinical Immunology, Milano, Italy 2013
Offerman N, Plum M, Hübner U, Fooke M, Spillner E. Establishment of Artificial Human Sera (ARTHUS) based on Chimeras of FcyRI and Human Immunogloblin G4 (IgG4) Domains. 37th Congreass of the European Academy of Allergology and Clinical Immunology, Helsinki, Dinnland 2017

Manuscripts

Kleine-Tebbe J, Breuer K, Lepp U, Vieths S, Worm M, Kunkel G, Wahn U und Lau S: Spezifische IgE-Werte gegen Aero- und Nahrungsmittelallergene im Vergleich: Dr. Fooke ALLERG-O-LIQ und Pharmacia CAP-System. Allergologie 2004, 27: 129-135.
Mahler M, Raijmakers R, Dähnrich C, Blüthner M and Fritzler MJ: Clinical evaluation of autoantibodies to a novel PM/Scl peptide antigen. Arthritis Research & Therapy 2005, 7: R704-R713.
Mahler M, Fritzler MJ: Anti-dsDNA antibody testing in the clinic: Farr or ELISA? Nat Clin Pract Rheumatol 2007, 3:72-3.
Mahler M, Raijmakers R: Novel aspects of autoantibodies to the PM/Scl complex: Clinical, genetic and diagnostic insights. Autoimmun Rev 2007, 6:432-7.
Mahler M, Waka A, Hiepe F, Fritzler MJ: Effect of dsDNA binding to SmD-derived peptides on clinical accuracy in the diagnosis of systemic lupus erythematosus. Arthritis Res Ther 2007, 9:R68.
Mahler M, Greidinger EL, Szmyrka M, Kromminga A, Fritzler MJ: Serological and Clinical Characterization of Anti-dsDNA and Anti-PM/Scl Double-Positive Patients. Ann N Y Acad Sci 2007, 1109:311-21.
Kessenbrock K, Raijmakers R, Fritzler MJ, Mahler M: Synthetic Peptides: The Future of Patient Management in Systemic Rheumatic Diseases? Curr Med Chem 2007, 14:2831-8.
Lucassen R, Fooke M, Kleine-Tebbe J, Mahler M: Development and Evaluation of a Rapid Assay for the Diagnosis of IgE-mediated Type I Allergies. J Investig Allergol Clin Immunol 2008, 18:223-4.
Sun B, Mahler M, Mei J, Jing L, Zhong N: Allergen-specific IgE to inhalant and food allergens and total IgE values in China – Comparison between two commercial immunoassays: Dr. Fooke ALLERG-O-LIQ versus Phadia ImmunoCAP® System. J Invest All Clin Immunol 2008, 18:319-321.
Mahler M, Ngo J, Schulte-Pelkum J, Luettich T, Fritzler MJ: Limited reliability of the indirect immunofluorescence technique for the detection of anti-Rib-P antibodies. Arthritis Res Ther 2008, 10:R131.
Mahler M, Fritzler MJ: PM1-Alpha ELISA: The assay of choice for the detection of anti-PM/Scl autoantibodies? Autoimmun Rev 2009, 8:373-378.
Schulte-Pelkum J, Fritzler M, Mahler M: Latest update on the Ro/SS-A autoantibody system. Autoimmun Rev 2009, 8:632-637.
Mahler M, Fritzler MJ: The changing landscape of the clinical value of the PM/Scl autoantibody system. Arthritis Res Ther 2009, 11: 106.
Mahler M, Fritzler MJ: AIT test has no problem in the detection of anti-ribosomal P- authors´ response. Arthritis Res Ther 2009, 11:411.
Mahler M, Fritzler MJ: Epitope specificity and significance in systemic autoimmune diseases. Ann N Y Acad Sci 2010, 1183: 267-287.
Lucassen R, Schulte-Pelkum J, Csuvarszki C, Kleine-Tebbe J, Fooke M, Mahler M: Evaluation of a Novel Rapid Test System for the Detection of Allergic Sensitization to Timothy Grass Pollen against Established Laboratory Methods and Skin Prick Test. Journal of Allergy 2010, Volume 2010: 1-4.
Mahler M, Silverman ED, Schulte-Pelkum J, Fritzler MJ: Anti-Scl-70 (topo-I) antibodies in SLE: Myth or reality? Autoimmun Rev 2010.
Maes L, Blockmans D, Verschueren P, Westhovens R, De Beeck KO, Vermeersch P et al.: Anti-PM/Scl-100 and anti-RNA-polymerase III antibodies in scleroderma. Clin Chim Acta 2010, 411: 965-971.
Mahler M, Maes L, Blockmans D, Westhovens R, Bossuyt X, Riemekasten G et al.: Clinical and serological evaluation of a novel CENP-A peptide based ELISA. Arthritis Res Ther 2010, 12: R99.
Mahler M, You D, Baron M, Taillefer SS, Hudson M, Fritzler MJ: Anti-centromere antibodies in a large cohort of systemic sclerosis patients: comparison between immunofluorescence, CENP-A and CENP-B ELISA. Clin Chim Acta 2011, 412: 1937-1943
Mahler M, gmon-Levin N, van LM, Shoenfeld Y, Waka A, Hiepe F et al.: Multi-center evaluation of autoantibodies to the major ribosomal P C22 epitope. Rheumatol Int 2012, 32: 691-698.
Pfender N, Lucassen R, Offermann N, Schulte-Pelkum J, Fooke M, Jakob T: Evaluation of a novel rapid test system for the detection of specific IgE to hymenoptera venoms. Journal of Allergy 2012, 2012: 1-7.
Offermann N, Conrad K, Fritzler MJ, Fooke-Achterrath M: Development and validation of a lateral flow assay (LFA) for the determination of IgG-antibodies to Pr3 (cANCA) and MPO (pANCA). J Immunol Methods 2013 Nov 27 [Epub 2013 Nov 27].
Feyzkhanova GU, Filippova MA, Talibov VO, Dementieva EI, Maslennikov VV, Reznikov YP, Offermann N, Zasedatelev AS, Rubina AY, Fooke-Achterrath M: Development of hydrogel biochip for in vitro allergy diagnostics. J Immunol Methods 2014 Apr [Epub 2014 Mar 12].
Offermann N, Plum M, Hubner U, Rathloff K, Braren I, Fooke M, Spillner E: Human serum substitution by artificial sera of scalable allergen reactivity based on polyclonal antibodies and chimeras of human FcgammaRI and IgE domains. Allergy 2016.
Crameri R. Artificial human sera: a breakthroug? Allergy 2016

Book Chapters

Eisfeller P, Pepperkok B, Luettich T, Mahler M, Jauris C, Fritzler MJ: The association of anti –SS-A/ Ro52 and anti-SS-A/Ro60 antibodies in different connective tissue diseases. In Prediction and Early Diagnosis of Disease by Autoantibodies: Reports on the 8^th Dresden Symposium on Autoantibodies. Edited by Conrad K, et al., Lengerich: Pabst Science Publishers; 2007.
Mahler M, Fritzler MJ: Novel aspects of autoantibodies to the human exosome (PM/Scl complex): Reports on the 8^th Dresden Symposium on Autoantibodies. Edited by Conrad K, et al., Lengerich: Pabst Science Publishers; 2007.
Mahler M, Fritzler MJ: Peptide resolved diagnostics in systemic autoimmune diseases: Potentials and Pitfalls. Reports on the 9^th Dresden Symposium on Autoantibodies. Edited by Conrad K, et al., Lengerich: Pabst Science Publishers; 2009.
Schulte-Pelkum J. Serological Aspects of Myositis: Idiopathic Inflammatory Myopathies – Recent Developments. Edited by Gran JT, Rijeka: Intech; 2011. 25-42.